Synopsis
The central mechanisms underlying Fibromyalgia syndrome remain undetermined; however, there is increasing evidence to suggest that neurochemical imbalances may play a critical role in the pathophysiology of the condition. The DLPFC is a heterogeneous cortical structure involved in cognitive, affective, and sensory processing of pain known to mediate top down pain modulation. We provide the first evidence of excitatory/inhibitory imbalance within the DLPFC in fibromyalgia syndrome, which we demonstrated to be positively associated with acute/clinical pain measures and the degree of resting state functional connectivity to affective pain circuitry (dorsal anterior cingulate cortex). Together these results suggest a dysregulation of excitation and inhibition in top-down pain modulatory networks with potential pathophysiological implications in pain processing. Furthermore, this evidence provides potential pharmacological and neuromodulatory therapeutic targets for the treatment of fibromyalgia syndrome.
Disclosures
- Nothing to disclose by any authors.
Author(s):
- James H. Bishop, PhD, Postdoctoral Fellow, Stanford University
- Afik Faerman, BA, Graduate Student, Stanford University
- Andrew D. Geoly, MS, Stanford University
- Adi Maron-Katz, PhD, Postdoctoral Fellow, Stanford University
- Matthew D. Sacchet, PhD, Instructor, Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School
- David Spiegel, MD, Professor, Department of Psychiatry & Behavioral Sciences, Stanford University
- Dr. Nolan R. Williams, MD, Director of the Stanford Brain Stimulation Lab, Stanford Hospital and Clinics
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Altered Neurochemical Ratio in the Prefrontal Cortex is Associated with Pain in Fibromyalgia Syndrome
Synopsis
The central mechanisms underlying Fibromyalgia syndrome remain undetermined; however, there is increasing evidence to suggest that neurochemical imbalances may play a critical role in the pathophysiology of the condition. The DLPFC is a heterogeneous cortical structure involved in cognitive, affective, and sensory processing of pain known to mediate top down pain modulation. We provide the first evidence of excitatory/inhibitory imbalance within the DLPFC in fibromyalgia syndrome, which we demonstrated to be positively associated with acute/clinical pain measures and the degree of resting state functional connectivity to affective pain circuitry (dorsal anterior cingulate cortex). Together these results suggest a dysregulation of excitation and inhibition in top-down pain modulatory networks with potential pathophysiological implications in pain processing. Furthermore, this evidence provides potential pharmacological and neuromodulatory therapeutic targets for the treatment of fibromyalgia syndrome.
Disclosures
- Nothing to disclose by any authors.