Synopsis

Here we propose a characterization of Fibromyalgia pathophysiology in gray matter (GM) tissue using a multimodal neuroimaging approach (volumetric, diffusion-weighted, and resting-state functional connectivity).

Disclosures

Nothing to Disclose by any Author

Synopsis

In order to overcome barriers to adoption of neurostimulation technologies by patients and clinicians, we present here a minimally invasive needle placeable and fully implanted neurostimulator that is suitable for clinical imaging (U/S, X-Ray, MRI). The structural design and placement procedure of the injectable helical wire structure electrode (Injectrode) renders the device self anchoring and deliverable using a minimal number of components. Demonstrated are placements by clinicians on various nerve targets in animal and human models.

Disclosures

• Stephan Nieuwoudt is employed by and owns equity in Neuronoff, Inc. 
• Amelia Howe is employed by and owns equity in Neuronoff, Inc. 
• Johanna Pearson is employed by Neuronoff, Inc. 
• Emily Szabo is employed by and owns equity in Neuronoff, Inc. 
• Morgan McGaughey is employed by and owns equity in Neuronoff, Inc. 
• Derrick Liu is employed by and owns equity in Neuronoff, Inc. 
• Shaher Ahmad is employed by and owns equity in Neuronoff, Inc. 
• Kip A. Ludwig is receiving funds from and owns equity in Neuronoff, Inc.
• Hesham Elsharkawy owns equity in Neuronoff, Inc. 
• Amol Soin owns equity in Neuronoff, Inc. 
• Alaa Abd-Elsayed owns equity in Neuronoff, Inc. 
• Manfred Franke is employed by and owns equity in Neuronoff, Inc. 
• Andrew J. Shoffstall is receiving funds from and owns equity in Neuronoff, Inc.
• This project is supported by Neuronoff Inc., NIH 1U18EB029251-01 Grant, and the DARPA EEI program. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Department of Defense or the National Institutes of Health.

Synopsis

Post dural puncture headaches are, more recently, being documented as a complication related to spinal cord stimulator placement. Dural compromise are usually appreciated prior to this condition's onset. A viable treatment for post dural headaches is epidural blood patches. Less reported in literature still, is the presence of post dural headache after leads removal from a trail spinal cord stimulator, when initial placement of the spinal cord stimulator was without noted dural compromise and tolerated by the patient well prior to its removal.  

Disclosures

Nothing to Disclose by any Author

Synopsis

The COVID pandemic may have affected gender disparities in research publication, which serves as a proxy for academic productivity and often leads to academic promotion. In the years 2019 and 2020, there was a significant gender-related disparity in actual publications in peer-reviewed high-impact pain journals. In those years, first-author gender did not affect original research where protocols blind reviewers to potential authors' names and other demographics. A gender disparity occurred in non-original research (p=0.047). Bivariate analysis did not show any association between gender and time, suggesting the COVID pandemic did not play a significant role in these disparities.

Disclosures

Nothing to Disclose by any Author

Synopsis

Transitional pain services (TPS) can be effective in addressing chronic postsurgical pain and opioid tapering; however, it has not been used widely or within a solely virtual setting. Using a commercial virtual transitional pain (vTPS) service which identifies patients for chronic pain and opioid dependency risk prior to surgery, we present a case study on a veteran undergoing TJA. Our findings show that providing comprehensive pain management care, including pre- and post-surgery psychological support for a veteran who is at medium-to-high relative risk for chronic pain and opioid dependency after TJA is effective through a virtual TPS program.

Disclosure

• MH, BN, AZ are full-time employees of Lucid Lane, the commercial sponsor of this study.
• MH, BN, and AZ receive funding from and have equity in Lucid Lane.
• The remaining authors have no disclosures.

Synopsis

Stellate ganglion cryoablation is a safe, efficacious treatment option for Complex Regional Pain Syndrome (CRPS) that has good outcomes and longer lasting effects than ganglion blocks.

Disclosures

Nothing to Disclose

Synopsis

Head/neck cancer patients experience high pain after surgery, putting them at risk for persistent postoperative opioid use. Using a comprehensive CBT-facilitated telehealth platform seems to be beneficial and approachable for head/neck cancer patients (n = 6) to adequately manage pain after surgery, and ultimately taper 100% off post-surgical opioids. Reduction and cessation of new and persistent opioid use after surgery is possible for head/neck cancer patients.

Disclosures

• MH, BN, AZ are full-time employees of Lucid Lane, the commercial sponsor of this study.
• MH, BN, and AZ receive funding from and have equity in Lucid Lane.
• CH is an advisor at Lucid Lane and provides consultations.
• The remaining authors have no disclosures.

Synopsis

There are a multitude of reasons for which neuromodulation devices must occasionally be removed or explanted from a patient. Unfortunately, this process often leads to fractured leads and/or fragments of leads left in the patient, due to limiting design features of current technologies. Here we demonstrate a reliable procedure by which an injectable helical wire structure electrode (Injectrode) may be removed easily, quickly, completely, and robustly from benchtop phantom and preclinical models.

Disclosures

• Manfred Franke is employed by and has equity in Neuronoff, Inc.
• Amelia Howe is employed by and has equity in Neuronoff, Inc.
• Stephan Nieuwoudt is employed by and has equity in Neuronoff, Inc.
• Emily Szabo is employed by and has equity in Neuronoff, Inc.
• Jacob Conard is employed by Neuronoff, Inc.
• Morgan McGaughey is employed by and has equity in Neuronoff, Inc.
• Derrick Liu is employed by and has equity in Neuronoff, Inc.
• Shaher Ahmad is employed by and has equity in Neuronoff, Inc.
• Kip A. Ludwig is receiving funding and has equity in Neuronoff, Inc.
• Amol Soin has equity in Neuronoff, Inc.
• Alaa Abd-Elsayed has equity in Neuronoff, Inc.
• Andrew J. Shoffstall is receiving funding and has equity in Neuronoff, Inc.
• This project is supported by Neuronoff Inc., NIH 1U18EB029251-01 Grant, and the DARPA EEI program. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Department of Defense or the National Institutes of Health

Synopsis

This is the first known published case of its kind on the successful use of cervical spinal cord stimulation for the treatment of chronic and severe pain in the left chest and left shoulder that was of unknown origin despite extensive workup and was refractory to a plethora of treatments including medical management, alternative management, surgery, interventional procedures.

Disclosures

Nothing to Disclose by any Author

Synopsis

Using data obtained from the Deciphering Epigenomic effects of Stress and Aging (SEAC) and EMR Pain related data and biobank (EMR) studies, detailed socioeconomic phenotypes in participants over 55 years old with chronic musculoskeletal pain were characterized by distinct subgroups differing across several pain and clinical variables. We aimed to test socioeconomic phenotype profile differences across five predictors of biological aging previously related to pain and function.

Disclosures

No conflicts of interest/disclosures