Synopsis
A hyperexcitable central nervous system, i.e. central sensitization, is a potential pathophysiological mechanism contributing to chronic pain. This study aims to advance the understanding of central sensitization in patients with chronic low back pain (CLBP) using psychophysical assessments and brain imaging methods. Preliminary results of 31 CLBP patients suggest that psychophysical measures of spinal and supraspinal pain modulation depend on used stimulus modality and body region, i.e., painful versus non-painful body region. A multimodal approach integrating the psychophysical assessments with brain imaging measures might provide novel insights into central sensitization in CLBP.
Disclosures
Display Label | Action |
---|---|
Poster - NPC2021 - Sirucek - Multimodal Assessment of Sensitization | Download Poster |
Abstract - NPC2021 - Sirucek - Multimodal Assessment of Spinal and Supraspinal Sensitization in Patients with Chronic Low Back Pain | Download Abstract |
Synopsis
A hyperexcitable central nervous system, i.e. central sensitization, is a potential pathophysiological mechanism contributing to chronic pain. This study aims to advance the understanding of central sensitization in patients with chronic low back pain (CLBP) using psychophysical assessments and brain imaging methods. Preliminary results of 31 CLBP patients suggest that psychophysical measures of spinal and supraspinal pain modulation depend on used stimulus modality and body region, i.e., painful versus non-painful body region. A multimodal approach integrating the psychophysical assessments with brain imaging measures might provide novel insights into central sensitization in CLBP.
Disclosures