29th Napa Pain Conference (2022) - 2022 NPC Poster Hall - Neurovations

Multimodal Assessment of Spinal and Supraspinal Sensitization in Patients with Chronic Low Back Pain




Synopsis

A hyperexcitable central nervous system, i.e. central sensitization, is a potential pathophysiological mechanism contributing to chronic pain. This study aims to advance the understanding of central sensitization in patients with chronic low back pain (CLBP) using psychophysical assessments and brain imaging methods. Preliminary results of 31 CLBP patients suggest that psychophysical measures of spinal and supraspinal pain modulation depend on used stimulus modality and body region, i.e., painful versus non-painful body region. A multimodal approach integrating the psychophysical assessments with brain imaging measures might provide novel insights into central sensitization in CLBP.


Disclosures

  • The authors have no conflict of interest – financial or otherwise – to declare.
  • This study is funded by the Clinical Research Priority Program University of Zurich CRPP “Pain”
  • BW was supported by the Swiss Association of Chiropractic "ChiroSuisse"

Author(s):
  • Laura Sirucek, MSc, PhD Trainee, Integrative Spinal Research Group, Balgrist University Hospital
  • Brigitte Wirth, PhD, Senior Researcher, University of Applied Sciences
  • Mirjam Baechler, DC, MMEd, Clinical Researcher, Integrative Spinal Research Group, Balgrist University Hospital, University of Zurich
  • Lucas Tauschek, BSc, Research Assistant, Integrative Spinal Research Group, Balgrist University Hospital, University of Zurich
  • Anke Langenfeld, PhD, Postdoc, Integrative Spinal Research Group, Balgrist University Hospital, University of Zurich
  • Leonie Hofstetter, DCM, Clinical Fellow, Integrative Spinal Research Group, Balgrist University Hospital, University of Zurich
  • Melanie Haeusler, MChiroMed, Clinical Fellow, Integrative Spinal Research Group, Balgrist University Hospital, University of Zurich
  • Niklaus Zoelch, PhD, Research Assistant, Department of Forensic Medicine and Imaging, Institute of Forensic Medicine, University of Zurich
  • Prof. Christian Beckmann, PhD, Principal Investigator, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center
  • Dr. Petra Schweinhardt, MD, PhD, Head of Research, Integrative Spinal Research Group, Balgrist University Hospital, University of Zurich

Track: Poster

Tags: Clinical Research Low Back Pain Central Sensitization Neuroimaging Oral Poster

Display Label Action
Poster - NPC2021 - Sirucek - Multimodal Assessment of Sensitization Download Poster
Abstract - NPC2021 - Sirucek - Multimodal Assessment of Spinal and Supraspinal Sensitization in Patients with Chronic Low Back Pain Download Abstract

Please use this thread to discuss the following:


Multimodal Assessment of Spinal and Supraspinal Sensitization in Patients with Chronic Low Back Pain


Synopsis

A hyperexcitable central nervous system, i.e. central sensitization, is a potential pathophysiological mechanism contributing to chronic pain. This study aims to advance the understanding of central sensitization in patients with chronic low back pain (CLBP) using psychophysical assessments and brain imaging methods. Preliminary results of 31 CLBP patients suggest that psychophysical measures of spinal and supraspinal pain modulation depend on used stimulus modality and body region, i.e., painful versus non-painful body region. A multimodal approach integrating the psychophysical assessments with brain imaging measures might provide novel insights into central sensitization in CLBP.


Disclosures

  • The authors have no conflict of interest – financial or otherwise – to declare.
  • This study is funded by the Clinical Research Priority Program University of Zurich CRPP “Pain”
  • BW was supported by the Swiss Association of Chiropractic "ChiroSuisse"