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24th Napa Pain Conference

NPC2017-F03 - Understanding the Pain Response: Clinical Implications of Glial Dysregulation of Pain & Opioid Actions


Aug 18, 2017 9:00am ‐ Aug 18, 2017 10:15am



Credits: None available.

Description

OVERVIEW

This lecture explains the link between immunology and pain.

At completion of the lecture, participants will be knowledgeable about the role of peripheral immune cells and glial cells in amplification of pain, and their growing importance in the understanding of pathological pain states.


LEARNING OBJECTIVES

As a result of completing this course, learners will be able / better able to:

  • Apply an increased understanding of the role that peripheral immune cells and glial cells play in the amplification of pain and their growing importance in the understanding of pathological pain states.

RESOURCES

  • Kwilasz, A.J., Grace, P.M., Serbedzija, P., Maier, S.F. & Watkins, L.R., The therapeutic potential of interleukin-10 in neuroimmune diseases, Neuropharmacology Special Issue on Neuroimmunology and Synaptic Function, 96 (2015) 55-69.
  • Grace, P.M., Hutchinson, M.R., Maier, S.F. & Watkins, L.R., Pathological pain and the neuroimmune interface. Nature Reviews Immunology, 14 (2014) 217-231.
  • Nicotra, L, Loram, L., Watkins, L.R. & Hutchinson, M.R., Toll like receptors in chronic pain, Experimental Neurology Special Issue on Microglia and Chronic Pain, 234 (2012) 316-29.
  • Hutchinson, M.R., Shavit, Y., Grace, P.M., Rice, K.C., Maier, S.F. & Watkins, L.R., Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia, Pharmacological Reviews 63 (2011) 722-810.
  • Watkins, L.R., Hutchinson, M.R., Rice, K., & Maier, S.F., The “toll” of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia, Trends in Pharmacological Sciences, 30 (2009) 581-591.
  • Milligan, E.D. and Watkins, L.R., Pathological and protective roles of glia in chronic pain, Nature Neuroscience Reviews, 10 (2009) 23-36.
  • Watkins, Linda R., Erin D. Milligan, and Steven F. Maier. “Glial activation: a driving force for pathological pain.” Trends in Neurosciences 8 (2001): 450-455.

Learning Objective:
  • Apply an increased understanding of the role that peripheral immune cells and glial cells play in the amplification of pain and their growing importance in the understanding of pathological pain states.

Speaker(s):

  • Linda Watkins, PhD, Professor, Department of Psychology, and Director, Interdepartmental Neuroscience PhD Program, University of Colorado
Category: CME

Credits

Credits: None available.

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