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27th Napa Pain Conference Sessions

Preventing Pandemics & Preparing Health Care



Expiration Date: Aug 14, 2023


Credits: None available.

Standard: $59.95

Description

COVID-19, Lung Insufficiencies, Fractal Geometry & Hyperactivity of the Inflammatory System


Outline

  • Evolution of Pandemics
  • 3 P´s for Pandemics
  • Understanding the pandemic disease
  • Some Health Care Challenges
  • Conclusion

Accreditation & Designation

Release date: This activity was released 8/15/2020.

Termination date: The content of this activity remains eligible for CME Credit until 8/14/2023, unless reviewed or amended prior to this date.

Neurovations Education is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Neurovations Education designates this Other (blended learning) activity for a maximum of 1.00 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


Desirable Physician Attributes

  • Medical Knowledge [ACGME/ABMS] about established and evolving biomedical, clinical, and cognate (e.g. epidemiological and social-behavioral) sciences and the application of this knowledge to patient care
  • Employ Evidenced-based Practice [IOM] Integrate best research with clinical expertise and patient values for optimum care, and participate in learning and research activities to the extent feasible
  • Systems-Based Practice [ACGME/ABMS] as manifested by actions that demonstrate an awareness of and responsiveness to the larger context and system of health care and the ability to effectively call on system resources to provide care that is of optimal value

References

  • Lindahl, S. G. (2020). Using the prone position could help to combat the development of fast hypoxia in some patients with COVID‐19. Acta Paediatrica.
  • de Groot, R. J., Baker, S. C., Baric, R. S., Brown, C. S., Drosten, C., Enjuanes, L., ... & Perlman, S. (2013). Commentary: Middle east respiratory syndrome coronavirus (mers-cov): announcement of the coronavirus study group. Journal of Virology, 87(14), 7790-7792.
  • Woo, P. C., Lau, S. K., Lam, C. S., Lau, C. C., Tsang, A. K., Lau, J. H., ... & Zheng, B. J. (2012). Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus. Journal of Virology, 86(7), 3995-4008.
  • Forni, D., Cagliani, R., Clerici, M., & Sironi, M. (2017). Molecular evolution of human coronavirus genomes. Trends in Microbiology, 25(1), 35-48.
  • Ye, Z. W., Yuan, S., Yuen, K. S., Fung, S. Y., Chan, C. P., & Jin, D. Y. (2020). Zoonotic origins of human coronaviruses. International Journal of Biological Sciences, 16(10), 1686.
  • Gussow, A. B., Auslander, N., Faure, G., Wolf, Y. I., Zhang, F., & Koonin, E. V. (2020). Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses. Proceedings of the National Academy of Sciences.
  • Wei, J., Alfajaro, M., Hanna, R., DeWeirdt, P., Strine, M., Lu-Culligan, W., ... & Mankowski, M. (2020). Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection. Biorxiv.
  • Tracey, K. J. (2015). Approaching the next revolution? Evolutionary integration of neural and immune pathogen sensing and response. Cold Spring Harbor Perspectives in Biology, 7(2), a016360.
  • Nicoli, F., Solis-Soto, M. T., Paudel, D., Marconi, P., Gavioli, R., Appay, V., & Caputo, A. (2020). Age-related decline of de novo T cell responsiveness as a cause of COVID-19 severity. GeroScience, 1-5.
  • Grifoni, A., Weiskopf, D., Ramirez, S. I., Mateus, J., Dan, J. M., Moderbacher, C. R., ... & Marrama, D. (2020). Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals. Cell.
  • Tracey, K. J. (2002). The inflammatory reflex. Nature, 420(6917), 853-859.
  • Andersson, U., Yang, H., & Harris, H. (2018). Extracellular HMGB1 as a therapeutic target in inflammatory diseases. Expert opinion on therapeutic targets, 22(3), 263-277.
  • Tracey, K. J. (2007). Physiology and immunology of the cholinergic antiinflammatory pathway. The Journal of Clinical Investigation, 117(2), 289-296.
  • Douglas, W. W., Rehder, K., Beynen, F. M., Sessler, A. D., & Marsh, H. M. (1977). Improved oxygenation in patients with acute respiratory failure: the prone position. American Review of Respiratory Disease, 115(4), 559-566.
  • Beck, K. C., & Rehder, K. (1986). Differences in regional vascular conductances in isolated dog lungs. Journal of Applied Physiology, 61(2), 530-538.

Disclosures of Financial Relationships

Neither the speaker, peer reviewers nor any other person with control of, or responsibility for, the development, management, presentation or evaluation of the CME activity has, or has had within the past 12 months, any relevant financial relationships to disclose. This includes any relationships of an involved person's spouse/partner.

Learning Objectives:
  • Always watch out for a possible pandemic and be prepare to take appropriate early-warning actions.
  • During an epidemic or pandemic, protect yourself by distancing, face masks, face shields and by being ready for isolation in quarantines.
  • Assimilate information on a new viral disease and communicate with the medical world and public health authorities.
  • Find as early as possible the most severe forms of disease in order to plan for structural re-organization.
  • [When applicable] Utilize the best available evidence-based clinical strategies to treat COVID-19-induced hypercoagulation and hyperinflammation

Speaker(s):

  • Prof. Sten Lindahl, MD, PhD, FRCA, Chair Emeritus, Nobel Committee in Physiology or Medicine

Disclosures

  • Sten Lindahl, MD, PhD, FRCA : I have no financial relationships to disclose.
Category: General Session

Credits

  • 1.00 - Physician
  • 1.00 - Non-Physician

You must be logged in and own this session in order to post comments.

Peter Staats
12/7/20 1:03 pm

GREAT lecture Sten.

Paul Leo
12/7/20 1:04 pm

Dr. L is as up to date as possible.

Yazmin Clark
12/7/20 1:06 pm

Good discussion with interesting points

Frank Hawkins
12/7/20 1:07 pm

Very nice presentation

Jeffrey Young
12/7/20 1:44 pm

There are reports of manifestations of encephalopathy already Also reports of post COVID chronic fatigue syndrome

Sri Nalamachu
12/7/20 1:46 pm

Great lecture, Dr. Lindahl

Maria Torres
12/7/20 1:47 pm

Appreciate the mechanistic explanation

Steven Levin
12/7/20 1:47 pm

Great talk. Thank you!

Michael Yang
12/7/20 1:48 pm

Thank you! Great talk!

Jamie Lytton
12/7/20 1:49 pm

Thank you great lecture

Michael Amster
12/7/20 1:54 pm

Excellent synopsis! Thank you!

Pankaj Thapar
12/7/20 1:57 pm

great talk

Rohit Nalamasu
12/7/20 1:59 pm

Thank you very much!

Patricia Ratliff
12/7/20 2:00 pm

Thank you. Great Lecture.

Anilkumar Vinayakan
12/7/20 2:01 pm

Great talk. Thanks

Khalida Anwar
12/7/20 2:02 pm

Great lecture

Talal Ghazal
12/7/20 2:03 pm

Great lecture.

Quanetta Bazile
12/7/20 2:04 pm

Thank you great lecture

Andrew Talbott
12/7/20 2:04 pm

Excellent!

Karl-Heinz Spittler
12/7/20 2:05 pm

Great lecture, thank you Sten

Elizabeth Snoderly
12/7/20 2:06 pm

Thanks for the information!

Obinna Uzodinma
12/7/20 2:06 pm

Thank you for lecture!

Mary Rocca
12/7/20 2:08 pm

Thank you Sten! Great presentation.

Lynn Cintron
12/7/20 2:09 pm

Thankyou. Excellent lecture.

Jack Berger
12/7/20 2:10 pm

outstanding review

Navtej Tung
12/7/20 2:11 pm

very informative presentation

Holly Kelly
12/7/20 2:14 pm

Applause!!!

Una Srejic
12/7/20 2:14 pm

superb lecture!

Cynthia Troiano
12/7/20 2:16 pm

Thank you!!!! Nice talk

Christine Vidouria
12/7/20 2:16 pm

Great

Rosfaiizah Siran
12/7/20 2:17 pm

Thank you. Great presentation

Shari Simon
12/7/20 2:18 pm

Great Lecture

Hillary Moss
12/7/20 2:19 pm

Great lecture, thank you!

Paul Phillips
12/7/20 2:21 pm

thank you. excellent

Peter Samuels
12/7/20 2:27 pm

Thank you!!

Carmen Quinones
12/7/20 2:29 pm

Excellent lecture. Thanks!!!

Maria Torres
12/7/20 2:32 pm

Great discussion of mechanisms from such an authority in the field

Daniel Carr
12/7/20 2:33 pm

Impressive lecture - thanks to Prof Lindahl and all who made it possible.

Khushvant Bhola
12/7/20 2:34 pm

Great Presentation

Susan Aull
12/7/20 2:36 pm

Excellent presentation, thank you.

Rosfaiizah Siran
12/7/20 2:38 pm

Applause. Thank you Prof Lindahl

Anagha Gadepalli
12/7/20 2:38 pm

Great lecture Dr. Lindahl

Angie Rakes
12/7/20 2:39 pm

Wonderful lecture!

Saroj Dubal
12/7/20 2:40 pm

Excellent lecture!!!

edgardo perez
12/7/20 2:41 pm

Excellent lecture to understand some elements in the pathophysiology. A truly academic presentation. Thanks Dr Lindahl

Jane Shipley
12/7/20 2:42 pm

Felix: Staats P, Giannakopoulos G, Blake J, Liebler E, Levy RM. The Use of Non-invasive Vagus Nerve Stimulation to Treat Respiratory Symptoms Associated With COVID-19: A Theoretical Hypothesis and Early Clinical Experience [published online ahead of print, 2020 Apr 27]. Neuromodulation. 2020;10.1111/ner.13172. doi:10.1111/ner.13172

Joysree Subramanian
12/7/20 2:43 pm

Awesome lecture!

Robert Riether
12/7/20 2:44 pm

Thank you for sharing your knowledge with us. The lecture was very informative.

Ripu Arora
12/7/20 2:45 pm

awesome lecture :-)

Carlos Martinez
12/29/20 12:19 am

Excellent information.