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Poor solubility of active pharmaceutical ingredients (API) can stall the delivery of bioavailable medications. Using naturally occurring compounds to act as solubilizers creates an extraordinary addition to the existing techniques. In feasibility studies, the class of a natural sweetener steviol glycosides was found to remarkably solubilize a plethora of tough-to-solubilize APIs. It also enabled the oily APIs to become water-soluble powder for delivery of various dosage forms and brighten the prospects of improved bioavailability.