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26th Napa Pain Conference

NPC26-Sa5-A - Mechanisms & Emerging Therapeutic Strategies for Treating Neuropathic Pain

Aug 17, 2019 2:00pm ‐ Aug 17, 2019 3:45pm


Mechanisms & Emerging Therapeutic Strategies for Treating Neuropathic Pain

Target Audience: Clinicians & researchers addressing acute or chronic pain

Learning Objectives

As a result of participating in this activity, learners will be better able to:

  • Apply an improved understanding of the pathophysiology of neuropathic pain to formulate treatment plans
  • Advocate with insurance payers for patient coverage for emerging therapies


Mesenchymal Stem Cell Therapy

Jianguo Cheng, MD, PhD, FIPP

Is Spinal Cord Stimulation an Appropriate Treatment for Chemotherapy-induced Neuropathy?

David J. Copenhaver, MD


Neuropathic pain is characterized by unpleasant symptoms, such as shooting or burning pain, numbness, altered sensation, and sensations that are very difficult to describe.

Although standard analgesics are relatively ineffective in neuropathic pain, treatment with mesenchymal stem cells and spinal cord stimulation demonstrate encouraging potential for clinical application and future research.

Additional Reading

  • Li, F., Liu, L., Cheng, K., Chen, Z., & Cheng, J. (2018). The use of stem cell therapy to reverse opioid tolerance. Clinical Pharmacology & Therapeutics, 103(6), 971-974.
  • Hua, Z., Liu, L., Shen, J., Cheng, K., Liu, A., Yang, J., ... & Wu, H. (2016). Mesenchymal stem cells reversed morphine tolerance and opioid-induced hyperalgesia. Scientific Reports, 6, 32096.
  • Chen, G., Park, C. K., Xie, R. G., & Ji, R. R. (2015). Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion. The Journal of Clinical Investigation, 125(8), 3226-3240.
  • English, K. (2013). Mechanisms of mesenchymal stromal cell immunomodulation. Immunology and Cell Biology, 91(1), 19-26.
  • Yakovlev, A. E., & Ellias, Y. (2008). Spinal cord stimulation as a treatment option for intractable neuropathic cancer pain. Clinical Medicine & Research, 6(3-4), 103-106.
  • Kim, J. H., Dougherty, P. M., & Abdi, S. (2015). Basic science and clinical management of painful and non-painful chemotherapy-related neuropathy. Gynecologic Oncology, 136(3), 453-459.
  • Hosseini, M., Yousefifard, M., Aziznejad, H., & Nasirinezhad, F. (2015). The effect of bone marrow–derived mesenchymal stem cell transplantation on allodynia and hyperalgesia in neuropathic animals: a systematic review with meta-analysis. Biology of Blood and Marrow Transplantation, 21(9), 1537-1544.
  • Yousefifard, M., Nasirinezhad, F., Manaheji, H. S., Janzadeh, A., Hosseini, M., & Keshavarz, M. (2016). Human bone marrow-derived and umbilical cord-derived mesenchymal stem cells for alleviating neuropathic pain in a spinal cord injury model. Stem Cell Research & Therapy, 7(1), 36.
  • Waterman, R. S., Morgenweck, J., Nossaman, B. D., Scandurro, A. E., Scandurro, S. A., & Betancourt, A. M. (2012). Anti‐inflammatory mesenchymal stem cells (MSC2) attenuate symptoms of painful diabetic peripheral neuropathy. Stem Cells Translational Medicine, 1(7), 557-565.
  • Cata, J. P., Cordella, J. V., Burton, A. W., Hassenbusch, S. J., Weng, H. R., & Dougherty, P. M. (2004). Spinal cord stimulation relieves chemotherapy-induced pain: a clinical case report. Journal of Pain and Symptom Management, 27(1), 72-78.
  • de Leon-Casasola, O. A. (2009). Spinal cord and peripheral nerve stimulation techniques for neuropathic pain. Journal of Pain and Symptom Management, 38(2), S28-S38.


  • Dr. Jianguo Cheng, MD, PhD, FIPP, Professor of Anesthesiology, Cleveland Clinic, Learner Research Institute & Case Western Reserve University
  • Dr. David J. Copenhaver, MD, Division Chief, Pain Medicine, UC Davis Health

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