Advances in the Management &
Treatment of Cancer Pain
Target Audience: Clinicians & researchers working in oncology or treating cancer-related pain
As a result of participating in this activity, learners will be better able to:
Determine when to use neurolytic blocks, targeted drug delivery, and dorsal punctate myelotomy
Identify patients who would benefit from targeted cancer therapies
Provide supportive care strategies for patients with multiple comorbidities
Innovative Treatment Algorithms
for Abdominal, Pelvic, Visceral Cancer Pain
David J. Copenhaver, MD
Risks/Benefits for Intrathecal Therapy Treatment Modalities
Lisa J. Stearns, MD
Visceral pain represents a major clinical problem, yet far less is known about its mechanisms compared to somatic pains, e.g. from cutaneous and muscular structures. Providers need an understanding of the neuroanatomical bases of visceral pain signaling in the peripheral and central nervous system.
Targeted drug delivery (TDD) has potential for cost savings compared with conventional medical management (CMM). Despite positive clinical and economic evidence, TDD remains underused to treat cancer pain.
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Aiyer, R., Mehta, N., Gungor, S., & Gulati, A. (2018). A systematic review of NMDA receptor antagonists for treatment of neuropathic pain in clinical practice. The Clinical Journal of Pain, 34(5), 450-467.
Dai, H., Tilley, D. M., Mercedes, G., Doherty, C., Gulati, A., Mehta, N., … & Reynolds, F. M. (2018). Opiate free pain therapy using carbamazepine loaded microparticles provides up to two weeks of pain relief in a neuropathic pain model. Pain Practice.
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Stearns, L. J., Hinnenthal, J. A., Hammond, K., Berryman, E., & Janjan, N. A. (2016). Health services utilization and payments in patients with cancer pain: a comparison of intrathecal drug delivery vs. Conventional medical management. Neuromodulation: Technology at the Neural Interface, 19(2), 196-205.
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Stearns, L. J., Narang, S., Albright, R. E., Hammond, K., Xia, Y., Richter, H. B., ... & Doth, A. H. (2019). Assessment of health care utilization and cost of targeted drug delivery and conventional medical management vs conventional medical management alone for patients with cancer-related pain. JAMA Network Open, 2(4), e191549-e191549.
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