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A multicenter, prospective, randomized controlled trial evaluated the effectiveness of differential target multiplexed SCS (DTM SCS) compared to traditional SCS during a 12-month period. Back pain responder rate (≥50% relief) of 80% with DTM SCS at the primary endpoint (3-month) was superior to the back pain responder rate of traditional SCS (51%). The response was sustained for 12 months (84% vs 51%). Furthermore, 69% of subjects receiving DTM SCS experienced profound back pain response (≥80% relief) compared to 35% of subjects receiving traditional SCS. Additional benefits were observed in quality of life, extent of disability, perceived improvement of change, and satisfaction.
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