How New Pain Therapies are Limited by Design

Therapeutic Promise vs. Potential: Limited by Design

Learning Objectives

As a result of participating in this activity, learners will be able/better able to:

• Apply an improved understanding of the trial and approval process to identify patients who are likely to respond, or not respond, to approved treatments

Desirable Physician Attributes

• Systems-based Practice [ACGME/ABMS] Awareness and responsiveness to larger context and system of health care, use of system resources
  
• Patient Care [ACGME/ABMS & IOM] Provide care that is compassionate, appropriate and effective for the treatment of health problems and the promotion of health
• Medical Knowledge [ACGME/ABMS] about established and evolving biomedical, clinical, and cognate (e.g. epidemiological and social-behavioral) sciences and the application of this knowledge to patient care
• Apply Quality Improvement [IOM} Identify errors and hazards in care; understand and implement basic safety design principles, such as standardization and simplification; continually understand and measure quality of care in terms of structure, process, and outcomes in relation to patient and community needs; and design and test interventions to change processes and systems of care, with the objective of improving quality
• Interpersonal and Communication Skills [ACGME/ABMS] Effective information exchange and teaming with patients, their families, and other health professionals

Accreditation & Designation

Release date: This activity was released 8/28/2021.

Termination date: The content of this activity remains eligible for CME Credit until 8/27/2024, unless reviewed or amended prior to this date.

Neurovations Education is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Neurovations Education designates this other activity (blended learning) for a maximum of 0.50 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosure of Financial Relationships & Measures to Resolve of Conflicts of Interest

[Presenter] W. Michael Hooten discloses the following financial relationships within the past 24 months: Research: US WorldMeds [Past relationship]

No other person with control of, or responsibility for, the planning, delivery, or evaluation of accredited continuing education has, or has had within the past 24 months, financial relationship(s) to disclose with ineligible companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

All relevant financial relationships have been mitigated. Materials were reviewed in advance of the activity by person(s) that do not have conflicts of interest related to the content. In some cases, content may have been modified as part of the review and mitigation process. All clinical recommendations are evidence-based and free of commercial bias (e.g., peer-reviewed literature, adhering to evidence-based practice guidelines).

Additional Reading

• Mannos, D. (2003). NCPS patient misidentification study: a summary of root cause analyses. VA NCPS Topics in Patient Safety. Washington, DC, United States Department of Veterans Affairs.
• D’Souza, R. S., Hooten, W. M., & Murad, M. H. (2021, August). A Proposed Approach for Conducting Studies That Use Data From Social Media Platforms. In Mayo Clinic Proceedings (Vol. 96, No. 8, pp. 2218-2229). Elsevier.
• Schwingler, P. M., Moman, R. N., Hunt, C., Ashmore, Z., Ogletree, S. P., Uvodich, M. E., ... & Hooten, W. M. (2021). Prevalence of postamputation pain and its subtypes: a meta-analysis with meta-regression. Pain Reports, 6(1).
• Fan, J., Jeffery, M. M., Hooten, W. M., Shah, N. D., & McCoy, R. G. (2021). Trends in Pain Medication Initiation Among Patients With Newly Diagnosed Diabetic Peripheral Neuropathy, 2014-2018. JAMA network open, 4(1), e2035632-e2035632.
• Boakye, M., Ugiliweneza, B., Madrigal, F., Mesbah, S., Ovechkin, A., Angeli, C., ... & Guest, J. (2021). Clinical trial designs for neuromodulation in chronic spinal cord injury using epidural stimulation. Neuromodulation: Technology at the Neural Interface, 24(3), 405-415.
• Gross, A. M. (2021). Using real world data to support regulatory approval of drugs in rare diseases: A review of opportunities, limitations & a case example. Current Problems in Cancer, 100769.
• Cartwright, N. (2009). If no capacities then no credible worlds. But can models reveal capacities?. Erkenntnis, 70(1), 45-58.