Mark Hoon PhD

Mark Hoon, PhD studies, at a molecular and cellular level, the basic neuroscience underlying the sense of somatosensation (hot, cold, pain, itch and the sense of touch), particularly the molecules that contribute to the detection, neural transmission and neuronal pathways employed by somatosensation. Molecular genetic approaches in combination with anatomical, pharmacological, and behavioral methods are used in mouse models to probe these neuronal components and circuits. These studies provide information about the mechanisms by which somatosensory stimuli are distinguished from each other, and the means by which distinct innate responses are elicited by these stimuli (for example the scratching that accompanies itch). Ultimately, these studies will reveal biologically relevant molecules and cell-types that are involved in sensing pain and itch, and will help identify potential targets for therapeutic intervention.